I've got a bad back, and so has my wife.
For both of us, the seats need to be firm, so that they hold us in place. However, the suspension needs to be pliable, so that you don't get bounced around all the time. Tyre size is (to me) really a part of the suspension. Again, you want a certain level of pliability in the sidewalls, so massive wheels with low profile tyres aren't the best things in the world. However, really soft wallowy suspension makes my wife horribly carsick. So it's a fine balancing act.
Hard seat and hard suspension and low-profile tyres is a bit like being dragged down the road on a teatray. Feeling every single bump is not my idea of fun
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