Hi Susan, not sure if you have resolved the problem but let me tell you it is not a turbo issue or anything previously mentioned.
I have an ML420 on 57 plate and had exactly the same problem as you. In particular when I used the car for over say 30 min journeys. What would happen would be a loss of power when I pushed the acelerator.
I had taken the car back to Mercedes many times before they told me that it was a system fault. Apparently what happens is the car thinks there is an engine critical problem and shuts itself down, moving into limp-home mode.
This is an ML420 fault and dont let Mercedes tell you otherwise. I am sure we are not the only ones suffering with it.
Anyway, eventually Merc fixed it (they told me the cost would be £690 but I would only need to pay £90 to cover the labour cost. Since it has been done (6 months?), I have only experienced the problem a couple of times.
Take it back to Merc and get them to do something. If they cannot identify the problem let me know and I will give you the contact details for my local dealership
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